Education B.Tech Chemical Engineering (Honors), Indian Institute of Technology, Kharagpur (IIT KGP), 2015.
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Proteins at air-water interfaces
Therapeutic proteins (specifically monoclonal antibodies) are surface active and adsorb onto air- protein solution interfaces. When this protein-laden interface is distorted during compression, cavitation and coalescence events, the proteins aggregate and are released into the solution as particulate matter affecting the potency, quality, safety and immunogenicity of the biologic therapeutics. We have developed a system to study these phenomena and to measure the interfacial rheology of the proteinaceous films and subsequently characterize the protein particles formed. Influence of surfactants, poloxamers as well as modifications to the proteins themselves are also being studied.